New World G60d -

hepatocyte nuclear factor 4 alpha wikipedia - hepatocyte nuclear factor 4 alpha hnf4a also known as nr2a1 nuclear receptor subfamily 2 group a member 1 is a nuclear receptor that in humans is encoded by the hnf4a gene, cytochrome p450 enzymes in drug metabolism regulation of - cytochromes p450 cyp are a major source of variability in drug pharmacokinetics and response of 57 putatively functional human cyps only about a dozen enzymes belonging to the cyp1 2 and 3 families are responsible for the biotransformation of most foreign substances including 70 80 of all drugs in clinical use